Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10¿801 women in 17 randomised trials

Early Breast Cancer Trialists' Collaborative Group (EBCTCG)

doi:10.1016/S0140-6736(11)61629-2

Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10¿801 women in 17 randomised trials

Early Breast Cancer Trialists' Collaborative Group (EBCTCG)

SHLS School Office

Research output: Contribution to journal › Article › peer-review

3085 Citations (Scopus)

Abstract

After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.

Original language	English
Pages (from-to)	1707-1716
Number of pages	10
Journal	Lancet
Volume	378
Issue number	9804
DOIs	https://doi.org/10.1016/S0140-6736(11)61629-2
Publication status	Published - Nov 2011

Keywords

radiotherapy
breast cancer
surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0140-6736(11)61629-2

Cite this

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title = "Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10¿801 women in 17 randomised trials",

abstract = "After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.",

keywords = "radiotherapy, breast cancer, surgery",

author = "S. Darby and P. McGale and C. Correa and C. Taylor and R. Arriagada and M. Clarke and D. Cutter and C. Davies and M. Ewertz and J. Godwin and R. Gray and L. Pierce and T. Whelan and Y. Wang and R. Peto and {Early Breast Cancer Trialists' Collaborative Group (EBCTCG)}",

year = "2011",

month = nov,

doi = "10.1016/S0140-6736(11)61629-2",

language = "English",

volume = "378",

pages = "1707--1716",

journal = "Lancet",

issn = "1474-547X",

publisher = "Elsevier B.V.",

number = "9804",

}

Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10¿801 women in 17 randomised trials. / Early Breast Cancer Trialists' Collaborative Group (EBCTCG).
In: Lancet, Vol. 378, No. 9804, 11.2011, p. 1707-1716.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10¿801 women in 17 randomised trials

AU - Darby, S.

AU - McGale, P.

AU - Correa, C.

AU - Taylor, C.

AU - Arriagada, R.

AU - Clarke, M.

AU - Cutter, D.

AU - Davies, C.

AU - Ewertz, M.

AU - Godwin, J.

AU - Gray, R.

AU - Pierce, L.

AU - Whelan, T.

AU - Wang, Y.

AU - Peto, R.

AU - Early Breast Cancer Trialists' Collaborative Group (EBCTCG)

PY - 2011/11

Y1 - 2011/11

N2 - After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.

AB - After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.

KW - radiotherapy

KW - breast cancer

KW - surgery

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-81055155920&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(11)61629-2

DO - 10.1016/S0140-6736(11)61629-2

M3 - Article

AN - SCOPUS:81055155920

SN - 1474-547X

VL - 378

SP - 1707

EP - 1716

JO - Lancet

JF - Lancet

IS - 9804

ER -

Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10¿801 women in 17 randomised trials

Abstract

Keywords

UN SDGs

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